Content deleted Content added
Line 4:
This virus appears to have evolved only recently. The first known strain was isolated in 1965. The strains fall into three taxa - named A, B and C. The C taxon appears to have evolved ~1970 while the A and B taxa evolved prior to this. An analysis of strains isolated in [[Europe]] ([[Austria]], [[France]] and [[Germany]]) showed that the clades C1b and C2b originated in 1994 (95% confidence interval 1992.7-1995.8) and 2002 (95% confidence interval 2001.6-2003.8) respectively.<ref name=Mirand2009>Mirand A, Schuffenecker I, Henquell C, Billaud G, Jugie G, Falcon D, Mahul A, Archimbaud C, Terletskaia-Ladwig E, Diedrich S, Huemer HP, Enders M, Lina B, Peigue-Lafeuille H, Bailly JL (2009) Phylogenetic evidence for a recent spread of two populations of human enterovirus 71 in European countries. J Gen Virol 91(9):2263-2277</ref>
==Virology==
The receptors for EV71 and CVA16 have been identified as [[P-selectin glycoprotein]] ligand-1 and [[scavenger receptor class B]], member 2 ([[SCARB2]]) both transmembrane proteins.<ref name=Nishimura2012>Nishimura Y and Shimizu H (2012) Cellular receptors for human enterovirus species A. Front Microbio 3:105 doi: 10.3389/fmicb.2012.00105 </ref>
==Pathology==
| |||